A report released in 2012 indicates that individuals with blood type a tend to be more prone to have A stroke prior to age 60 than individuals with other blood types.
The various blood types describe the assortment of chemical substances which are displayed on the surface area of our white blood cells. The most familiar tend to be those called A and B, that could be present as the AB, in part as a or B, and not present in any way because O.
You will find subtle variations with these major blood groups, because of mutations in the genetics.
Genomic studies have discovered a clear link between the A1 subgroup gene as well as early onset stroke.
The researchers collected information from forty eight genetic studies involving more or less 17,000 individuals with a stroke and almost 600,000 non-stroke controls. All participants had been between 18 and fifty nine years old.
A genome-wide search found 2 locations had been clearly linked with an earlier risk of stroke. One happened to coincide with the place where genetics for blood type reside.
A second analysis of particular types of blood type genes found that people whose genome coded for a variation of the a team had a 16 percent higher likelihood of strokes before the age of 60 in comparison with A population of other blood types.
The risk was 12 percent lower for individuals with a gene for the O1 group.
However the researchers say there is no need for increased vigilance or screening in this group as the added risk of stroke is tiny in individuals with type A blood.
“We still do not know the reason why blood type A might confer a greater risk,” said senior author as well as vascular neurologist Steven Kittner from the University of Maryland said in a 2022 statement.
“it most likely has something to do with blood clotting elements such as platelets and cells that line blood vessels in addition to other circulating proteins that play a role in the development of blood clots,” he said.
The findings that a particular blood type may increase or decrease premature stroke risk are alarming, but you have to be aware of how this study was carried out.
Just under 800,000 people suffer strokes each year in the United States. The majority of these events – about three out of every four – occur in people 65 years and older, with risks increasing every decade after the age of fifty five.
The individuals included in the research also lived in North America, Europe, Japan, Pakistan and Australia, with others of non-European ancestry making up only thirty five % of the participants. The significance of the results may be further clarified by future studies with a more diverse sample.
“We need to do a lot more follow-up studies to make clear the mechanisms of increased stroke risk,” Kittner said.
Another important finding of the study originated from comparing people that had a stroke ahead of the age of 60 to individuals which had a stroke after the age of sixty.
The scientists used a dataset of about 9,300 people over the age of 60 who had a stroke, and a few 25,000 control groups who had no stroke.
The investigators found that the increased risk of stroke in the type a team became small in the late onset stroke group, suggesting that strokes that happen at the beginning of life may have a unique mechanism.
Young people’s strokes are more apt to be caused by factors related to clot formation compared to those caused by a buildup of fatty deposits in the arteries, they claim.
The study also found that people with type B blood had been approximately 11 percent more likely to have a stroke compared to non-stroke controls, no matter their age.
Research studies suggest the part of the genome that codes for the blood type, known as the ABO locus’, is associated with heart attack and coronary artery calcification.
Genetic testing of your and B blood types has likewise been associated with A somewhat greater risk of blood clots in veins, A condition known as venous thrombosis.
This paper was published in Neurology.